职称：副研究员

系所：环境污染与健康研究所

办公室：校本部东区环化楼303室

电话：021-66137736

E-mail：peace74839@shu.edu.cn

个人简介

2005年获中国人民解放军军事医学科学院理学博士学位，2005-2007年中国人民解放军军事医学科学院公共卫生与预防医学流动站做博士后，2014-2015年赴美国纽约大学做访问学者。2007之后，任亚星221net，环境污染与健康研究所副研究员。主要研究方向为环境污染物（大气、水、土壤等）对人体的健康毒害作用及相关分子机理。中国毒理学会终身会员，替代及转化毒理学会委员会委员。主持国家自然科学基金2项，亚星221net创新项目1项，参与国家自然科学基金、973项目多项。获得国家发明专利2项，北京市科学技术奖三等奖一项，军队军队科技进步三等奖1项。近几年以第一作者/通讯作者发表SCI论文30余篇。培养硕士研究生十几名，有数名获得"国家奖学金"，"光华奖学金"，"上海市优秀毕业生"等称号。

学术经历

1995-2002年  获山东农业大学理学硕士学位

2002-2005年  获中国人民解放军军事医学科学院理学博士学位

2005-2007年  中国人民解放军军事医学科学院博士后

2014-2015年  美国纽约大学访问学者

研究方向

环境科学、环境毒理学、分子毒理学等。主要研究内容为环境物质（大气、水、土壤等）中有害成分的污染特征、对生物体及人体的生物学效应及分子调控机制。

代表成果

1. An J *, Hu JW, Yu S, Zhong YF, Zhang XY, Yu ZQ. The cytoxicity of organophosphate flame etardants on HepG2, A549 and Caco-2 cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2016, 51(11), 980-988.

2. Huang XM, Chen C, Shang Y, Zhong YF, Ren GF , Yu ZQ , An J *. In vitro study on the biotransformation and cytotoxicity of three hexabromocyclododecane diastereoisomers in liver cells. Chemosphere. 2016, 161: 251-258.

3. An J *, Guo PP, Yu S, Zhong YF, Zhang XY, Yu ZQ. The "adaptive responses" of low concentrations of HBCD in L02 cells and the underlying molecular mechanisms. Chemosphere. 2016, 145: 68-76.

4. Zhong YF, Guo PP, Wang X, An J *. Aroclor 1254 inhibits cell viability and induces apoptosis of human A549 lung cancer cells by modulating the intracellular Ca(2+) level and ROS production through the mitochondrial pathway. J Environ Sci Health A Tox Hazard Subst Environ Eng. 2015, 50(8): 806-813.

5. Zhong YF, Chen C, Wang X, Guo PP, An J *, Zhang XY, Yu ZQ. HBCD and PCBs enhance the cell migration and invasion of HepG2 via the PI3K/Akt pathway. Toxicol Res. 2015, 4(3):677-685

6. An J *, Wang X, Guo PP, Zhong YF, Zhang XY, Yu ZQ. Hexabromocyclododecane and polychlorinated biphenyls increase resistance of hepatocellular carcinoma cellsto cisplatin through the phosphatidylinositol 3- kinase/protein kinase B pathway. Toxicol Lett., 2014, 229, 265-272.

7. An J *, Chen C, Wang X, Zhong YF, Yu YX, Yu ZQ. Oligomeric Proanthocyanidins Alleviate Hexabromocyclododecane-Induced Cytotoxicity in HepG2 Cells through Regulation on ROS Formation and Mitochondrial Pathway. Toxicology in vitro. 2014. 28: 319–326.

8. Zou W, Chen C, Zhong YF, An J *, Yu YX, Yu ZQ *, Fu JM. PI3K/Akt Pathway Mediates Nrf2/ARE Activation in Human L02 Hepatocytes Exposed to Low-Concentration HBCDs. Environmental Science & Technology. 2013. 47(21): 12434-12440.

9. An J *, Zou W, Chen C, Zhong YF, Yu ZQ, Wang QJ *. The cytological effects of HBCDs on human hepatocyte L02 and the potential molecular mechanism. Journal of Environmental Science and Health, Part A. 2013. 48(11): 1333-1342.

10. Zang YS, Zhong YF, Fang Z, Li B *, An J *. MiR-155 inhibits the sensitivity of lung cancer cells to cisplatin via negative regulation of apaf-1 expression. Cancer Gene Therapy. 2012, 19: 773-778.

11. An J *, Zou W, Chen C, Zhong YF, Zhang XY, Wu MH, YuZQ, Ye TW *. The Toxic Effects of Aroclor 1254 Exposure on the Osteoblastic Cell Line MC3T3-E1 and its Molecular Mechanism. Toxicology. 2012, 295: 8-14.

12. Wang LL, Zou W, Zhong YF, An J *, Zhang XY, Wu MH, Yu ZQ. The hormesis effect of BDE-47 in HepG2 cells and the potential molecular mechanism. Toxicol Lett. 2012, 209:193-201.

13. Zhong YF, Wang LL, Yin LL, An J *, Hou ML, Zheng KW, Zhang XY, Wu MH, Yu ZQ, Sheng GY, Fu JM. Cytotoxic effects and oxidative stress response of six PBDE metabolites on human L02 cells. Journal of Environmental Science and Health, Part A. 2011，46：1320-1327.

14. An J, Yin L, Shang Y, Zhong YF, Zhang XY, Wu MH, Yu ZQ, Sheng GY, Fu JM, Huang YC *. The combined effects of BDE47 and BaP on oxidatively generated DNA damage in L02 cells and the possible molecular mechanism. Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 2011, 721:192–198.

15. Wang LL, Hou ML, An J*, Zhong YF, Wang XT, Wang YJ, Wu MH, Bi XH, Sheng GY, Fu JM. The Cytotoxic and Genetoxic Effects of Dust and Soil Samples from E-waste Recycling Area on L02 Cells. Toxicology and Industrial Health 2011, 27(9):831-837.

16. An J, Yang TY, Huang YC, Liu F, Sun JF, Wang Y, Xu QZ, Wu DC, and Zhou PK. Strand-specific PCR of UV radiation-damaged genomic DNA revealed an essential role of DNA-PKcs in the transcription-coupled repair. BMC Biochemistry 2011, 12:2.

17. An J *, Li SH, Zhong YF, Wang YP, Zhang XY, Zheng KW, Wu MH, Sheng GY, Fu JM, Huang YC *. The Cytotoxic Effects of Synthetic 6-Hydroxylated and 6-Methoxylated Polybrominated Diphenyl Ether 47 (BDE-47). Environmental Toxicology. 2011,26(6): 591-599.

18. An J, Huang YC, Xu QZ, Zhou LJ, Shang ZF, Huang B, Wang Y, Liu XD, Wu DC and Zhou PK. DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Molecular Biology, 2010, 11,18.

19. Zhou PK, Sun Y, An J. Interaction between viral proteins and hosts and its disturbance in the cellular responses to ionising radiation. Int J Radiat Biol. 2009, 85(7):587-97. 1.842

20. An J, Yang DY, Xu QZ, Huo YY, Bai B, Shang ZF, Zhang SM, Sui JL, Wu DC, Zhou PK. DNA-dependent protein kinase catalytic subunit regulates the stability of c-Myc oncoprotein through the Akt / GSK3 pathway. Molecular Cancer. 2008, 7:32.

21. An J, Xu QZ, Sui JL, Bai B, Zhou PK. Down-regulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in Hela cells. Int J Cancer. 2005, 117, 531-537.

22. An J, Xu QZ, Sui JL, Bai B and Zhou PK. Silencing of DNA-PKcs alters the transcriptional profile of certain signal transduction genes related to proliferation and differentiation in HeLa cells. Int J Mol Med, 2005, 16(3): 455-462.

23.尹灵灵，王流林，钟玉芳，安静*，吴明红 盛国英，傅家谟. BDE47的两种代谢产物对HepG2细胞中谷胱甘肽含量和P450酶活性的影响.亚星221net学报.2010, 16（6）：687-591.

24.赵金玉，钟玉芳，王艺陪，王杨君，安静*，盛国英，傅家. 6-OH多溴联苯醚47对A549细胞抗氧化系统的影响.亚星221net学报（自然科学版）. 2010,16（3）:302-305.

25.钟玉芳，尹灵灵，赵晓华，安静*. 6-羟基联合甲氧基-四溴联苯醚47对HepG-2的细胞毒性效应。环境与健康杂志. 2009,27(6)：64-67 .

专利目录

1.周平坤，安静，隋建丽，白贝.抑制DNA-PKcs蛋白表达的小干扰RNA分子及其编码基因与应用。国家发明专利，申请号：200410102568.0。已授权。公开日2006.07.05公告号：CN1796555

2.周平坤，安静，隋建丽.吩噻嗪类化学物在制备抑癌及辐射增敏药物中的应用。国家发明专利，专利号：ZL 03137011.X。已授权。公开日2004.12.08公告号：CN1552328

科研项目

1. 国家科技支撑计划课题（2014BAC21B04、2014/06-2018/06）：珠三角大气毒害污染物毒性评估技术、参与

2. 国家自然科学基金面上项目（21377080、2014/01-2017/12）：两种新型丁二烯代谢产物毒性、尿中生物标志物以及暴露人体中的存在研究、参与

3. 国家重点实验室开放基金项目（OGL-201212、2013/06-2014/12）：六溴环十二烷对肝癌细胞的毒性效应及代谢转化、主持

4. 国家自然科学基金面上项目（81072335、2011/01-2013/12）：BDE47介导的hormesis效应及其分子机制的研究、主持

5. 国家自然科学基金国际合作与交流项目（40910104012、2009/06-2009/11）：上海和东京大气细颗粒物的物化特征及生物活性比较研究、参与

6. 上海市教委创新基金项目（2009/01-2010/12）：PBDE蛋白质表达谱分析及分子标志物鉴定、主持

7. 科技部973项目（2008CB418205、2008/08-2012/07）：优控污染物暴露水平与途径、参与

8. 上海高校优秀青年教师科研专项基金（2008/01-2009/12）：DNA-PKcs调控c-myc蛋白稳定性的分子机理、主持

9. 国家自然科学基金面上项目（30672429、2007/01-2009/12）利用细胞内抗体捕获技术制备抗DNA-PKcs抗体及其靶向功能研究、参与。

10. 科技部973项目（2007CB914600、2007/01-2011/12）DNA损伤修复蛋白复合体及修复功能相关机制研究，参与

获奖情况

1. 周平坤，隋建丽，吴德昌，孙敬芬，范保星，葛世丽，安静，楼铁柱，胡迎春。粒子辐射细胞的遗传不稳定性与致癌危害性评价。军队科学技术进步奖二等奖，2005。

2. 周平坤，孙志贤，孙伟建，安静，孙薏，魏康。肿瘤细胞辐射抗性的分子基础及增敏措施研究。北京市科学技术奖三等奖, 2008.

教授课程

核心通识课《环境与绿色发展》