职称：副研究员（硕士生导师）

系所：环境污染与健康研究所

办公室：校本部东区环化楼327室

电话：021-66137734

Email：leibingli@126.com

个人简介

主持国家自然科学基金项目2项、省部级项目3项，水体污染控制与治理科技重大专项子课题1项，目前已发表论文50余篇。

学术经历

2006-2009年，中国科学院生态环境研究中心，环境科学，博士

2013 - 2014，北京大学，城市与环境学院，访问学者

研究方向

主要从事水环境化学与环境毒理学方面的研究。具体研究方向为：

1、新兴环境内分泌干扰物（如双酚类化合物、PPCP类化合物等）的内分泌干扰效应及分子机制;

2、区域水环境典型环境内分泌干扰物的筛查、甄别及风险评价。

代表成果

1、Bingli Lei，Su Sun，Xiaolan Zhang，Chenglian Feng，Jie Xu，Yu Wen, Yangen Huang, Minghong Wu, Yingxin Yu*. Bisphenol AF exerts estrogenic activity in MCF-7 cells through activation of Erk and PI3K/Akt signals via GPER signaling pathway. Chemosphere, 2019,220:362-370.

2、Bingli Lei,Yaoyao Huang, Yun Liu, Jie Xu, Su Sun, Xiaolan Zhang, Gang Xu, Minghong Wu, Yingxin Yu^*, Chenglian Feng^*. Low-concentration BPF induced cell biological responses by the ERαand GPER1-mediated signaling pathways in MCF-7 breast cancer cells. Ecotoxicol. Environ. Saf., 2018, 165: 144-152.

3、Bingli Lei^*，Su Sun，Jie Xu，Chenglian Feng，Yingxin Yu^*，Gang Xu，Minghong Wu，Wei Peng. Low-concentration BPAF- and BPF-induced cell biological effects are mediated by ROS in MCF-7 breast cancer cells. Environ. Sci. Pollut. Res. 2018,25(4):3200-3208.

4、Bingli Lei^*, Wei Peng,Gang Xu, Minghong Wu, Yu Wen, Jie Xu. Zhiaiqng Yu^*， Activation of G protein-coupled receptor 30 by thiodiphenol promotes proliferation of estrogen receptorα-positive breast cancer cells. Chemosphere, 2017,169:204-211.

5、Bingli Lei^*, Xu Jie, Peng Wei, Wen Yu, Zeng Xiangying, Yu Zhiqiang^*, Wang Yipei, In vitro profiling of toxicity and endocrine disrupting effects of bisphenol analogues by employing MCF-7 cells and two-hybrid yeast bioassay. Environ. Toxicol.2017, 32:278-289.

6、Bingli Lei^*, Wei Peng, Wei Li, Yingxin Yu, Jie Xu, Yipei Wang, Diethylstilbestrol at environmental levels affects the development of early life stage and target gene expression in Japanese Medaka (Oryzias latipes). Ecotoxicology 2016, 25: 563-573.

7、Lou Shufang, Lei Bingli^*, Feng Chenglian, Xu Jie, Peng Wei, Wang Yipei, In vitro toxicity assessment of sediment samples from Huangpu River and Suzhou River, Shanghai, China. Environ. Sci. Pollut. Res. 2016, 23:15183-15192.

8、Bingli Lei, Jia Kang, Xuetong Wang, Qian Liu, Zhiqiang Yu^*, Xiangying Zeng, Jiamo Fu, The toxicity of sediments from Taihu Lake evaluated by several in vitro bioassays. Environ. Sci. Pollut. Res., 2015, 22(5):3419-3430.

9、Bingli Lei, Kaiqiong Zhang, Jing An, Xinyu Zhang, Yingxin Yu^*. Human health risk assessment of multiple contaminants due to consumption of animal-based foods available in the markets of Shanghai, China. Environ. Sci. Pollut. Res., 2015, 22(6): 4434-4446.

10、Bingli Lei, Jia Kang, Yingxin Yu, Jinmiao Zha, Wei Li, Zijian Wang^*, Yipei Wang, Yu Wen, Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes).Comp. Biochem. Physiol. C, 2014, 160:86-92.

11、Bingli Lei, Jia Kang, Xuetong Wang, Yinxing Yu, Xiaolan Zhang^*, Yu Wen, Yipei Wang, The levels of PAHs and aryl hydrocarbon receptor effects in sediments of Taihu Lake, China. Environ. Sci. Pollut. Res., 2014, 21(10): 6547-6557.

12、Bingli Lei^*, Jia Kang, Yingxin Yu, Jinmiao Zha, Wei Li, Zijiang Wang,β-estradiol 17-valerate affects embryonic development and sexual differentiation in Japanese medaka (Oryzias latipes). Aquat. Toxicol., 2013, 134-135:128-134.

13、Bingli Lei^*, Yu Wen, Xuetong Wang, Jinmiao Zha, Wei Li, Zijian Wang, Yanfeng Sun, Jia Kang, Yipei Wang, Effect of estrone on the early life stages and expression of vitellogenin and estrogen receptor genes of Japanese medaka (Oryzias latipes). Chemosphere, 2013, 93(6):1104-1110.

14、Bingli Lei, Liang Chen, Ying Hao, Tiehua Cao, Xinyu Zhang, YingxinYu^*, Jiamo Fu, Trace elements in animal-based food from Shanghai markets and associated human daily intake and uptake estimation considering bioaccessibility. Ecotoxicol. Environ. Saf., 2013, 96:160-167.

科研项目

1、国家自然科学基金面上项目--ERs和GPER1介导的信号通路在氯代双酚A致Kisspeptin/GPR54-GnRH神经内分泌系统影响中的作用与机制（21777093），2018-2021，主持。

2、广东省环境催化与健康风险控制重点实验室开放基金--四氯双酚A对神经元细胞Kisspeptin/GPR54-GnRH神经内分泌信号的影响及作用机制（GKECHRC-02）2019-2021，主持。

3、国家自然科学基金青年基金项目--低剂量六氟双酚A对乳腺癌细胞生长的影响及非基因组信号转导机制研究（21507078）, 2016-2018主持。

4、有机地球化学国家重点实验室开放基金，OGL-2014010，六氟双酚A对乳腺癌细胞生长的影响及分子机制研究、2014-2016，主持。

5、上海市教育局--亚星221net青年骨干教师国内访问学者计划， 2013-2014，主持

6、亚星221net创新基金项目--区域水体雌激素的污染特征及生态风险评价，2010-2012，主持。

7、上海市优秀青年基金项目--上海水源地典型有毒有机污染物的筛查研究，2010-2012主持。

8、 水体污染控制与治理科技重大专项（2009ZX07528）亚星221net子课题--应急性与累积性水环境污染风险评价，2009-2012，主持。

9、"973"项目--湖泊水环境质量演变与水环境基准（2008CB418200）子课题--优控污染物暴露水平与途径，2008-2012，参加。

获奖情况

2017年论文学术"In vitro toxicity assessment of sediment samples from Huangpu River and Suzhou River, Shanghai, China"获河南省第四届自然科学学术奖---河南省自然科学优秀学术论文叁等奖，第二获奖人，共五人）

教授课程

研究生课程

环境污染与健康效应