职称：副研究员、硕导

系所：射线应用研究所

办公室：校本部东区环化楼610室

E-mail：sunhaoyu2021@shu.edu.cn

个人简介

孙昊宇，中共党员，长期从事hormesis（毒物兴奋）效应与机制及其应用研究，在探究hormesis广谱性及“跷跷板”机制的基础上建立hormesis与混合物联合毒性、细菌耐药性和中医阴阳理论的联系，推动hormesis效应在环境科学与工程领域的应用。先后获得国家自然科学基金青年项目、博士后创新人才支持计划、博士后基金面上项目、上海市“超级博士后”激励计划，并参与多项国家级科研项目。目前发表学术论文40余篇，其中以第一作者及通讯作者在环境领域专业期刊上发表SCI论文19篇；参与撰写专著《环境化学前沿》（书章节）1章。长期担任ES&T、CEJ、JHM、EP、STOTEN、Chemosphere、ER等环境领域主流期刊审稿人。

学术经历

2021.07-至今 亚星221net，亚星221net，副研究员

2019.03-2021.07 同济大学，土木工程学院，博士后

2015.09-2019.03 同济大学，环境科学与工程学院，博士

2012.09-2015.06 山东大学，环境科学与工程学院，硕士

2008.09-2012.06 河北科技大学，环境科学与工程学院，学士

研究方向

Hormesis（毒物兴奋）效应与机制；

污染物联合毒性与联合抗性及QSAR模型构建；

纳米材料抗菌性能及毒性评价；

中药提取物的抑菌活性与中药定量化研究。

代表成果

1. Hongyan Shen, Yinan Liu, Zemeng Duan, Pengpeng Wu, Zhifen Lin, Haoyu Sun*. Hormetic dose-responses for silver antibacterial compounds, quorum sensing inhibitors, and their binary mixtures on bacterial resistance of Escherichia coli, Science of The Total Environment, 786 (2021): 147464.

2. Qing Gao, Jing Wang, Longfei Ren, Yifei Cheng, Zhifen Lin, Xin-Gui Li, Haoyu Sun^*. Investigations on the influence of energy source on time-dependent hormesis: A case study of sulfadoxine to Aliivibrio fischeri in different cultivation systems, Science of The Total Environment, 775 (2021): 145877.

3. Xufei Li, Yajuan Wang, Yingying Liu, Zhifen Lin, Dali Wang, Haoyu Sun^*. Resistance risk induced by quorum sensing inhibitors and their combined use with antibiotics: Mechanism and its relationship with toxicity, Chemosphere, 265 (2021): 129153.

4. Xufei Li, Junyi Shi, Haoyu Sun^*, Zhifen Lin. Hormetic dose-dependent response about typical antibiotics and their mixtures on plasmid conjugative transfer of Escherichia coli and its relationship with toxic effects on growth, Ecotoxicology and Environmental Safety, 205 (2020): 111300.

5. Haoyu Sun^*, Edward J. Calabrese, Zhifen Lin, Baoling Chen, Xiaoxian Zhang. Similarities between the Yin/Yang Doctrine and Hormesis in Toxicology and Pharmacology, Trends in Pharmacological Sciences, 41 (2020): 544-556.

6. Haoyu Sun, Xinyue Zhang, Dali Wang, Zhifen Lin^*. Insights into the role of energy source in hormesis occurrence through diauxic growth of bacteria in mixed cultivation system, Chemosphere, 261 (2020): 127669.

7. Haoyu Sun^#, Yongzheng Pan^#, Xiang Chen, Wei Jiang, Zhifen Lin^*, Chunsheng Yin^*. Regular time-dependent cross-phenomena induced by hormesis: A case study of binary antibacterial mixtures to Aliivibrio fischeri, Ecotoxicology and Environmental Safety, 187 (2020): 109823.

8. Haoyu Sun, Zhifeng Yao, Dali Wang, Xiaodan Wu, Zhifen Lin^*, Ying Liu. A deep insight into the toxic mechanism for sulfonamides based on bacterial cell-cell communication, Environment International, 129 (2019): 185-193.

9. Haoyu Sun^#, Renhui Chen^#, Wei Jiang, Xiang Chen, Zhifen Lin^*. QSAR-based investigation on antibiotics facilitating emergence and dissemination of antibiotic resistance genes: A case study of sulfonamides against mutation and conjugative transfer in Escherichia coli, Environmental Research, 173 (2019): 87-96.

10. Haoyu Sun, Min Zheng, Jinyuan Song, Shengyou Huang, Yongzheng Pan, Ruochong Gong, Zhifen Lin^*. Multiple-species hormetic phenomena induced by indole: A case study on the toxicity of indole to bacteria, algae and human cells, Science of The Total Environment, 657 (2019): 46-55.

11. Haoyu Sun, Edward J. Calabrese, Min Zheng, Dali Wang, Yongzheng Pan, Zhifen Lin^*, Ying Liu. A swinging seesaw as a novel model mechanism for time-dependent hormesis under dose-dependent stimulatory and inhibitory effects: A case study on the toxicity of antibacterial chemicals to Aliivibrio fischeri, Chemosphere, 205 (2018): 15-23.

12. Haoyu Sun^#, Yongzheng Pan^#, Yue Gu, Zhifen Lin^*. Mechanistic explanation of time-dependent cross-phenomenon based on quorum sensing: A case study of the mixture of sulfonamide and quorum sensing inhibitor to bioluminescence of Aliivibrio fischeri, Science of The Total Environment, 630 (2018): 11-19.

13. Haoyu Sun^#, Hongming Ge^#, Min Zheng, Zhifen Lin^*, Ying Liu. Mechanism Underlying Time-dependent Cross-phenomenon between Concentration-response Curves and Concentration Addition Curves: A Case Study of Sulfonamides-Erythromycin mixtures on Escherichia coli, Scientific Reports, 6 (2016): 33718.

14. Haoyu Sun, Yingxue Liu, Meng Li, Songlin Han, Xudan Yang, Rutao Liu^*. Toxic effects of chrysoidine on human serum albumin: isothermal titration calorimetry and spectroscopic investigations, Luminescence, 31 (2016): 335-340.

15. Haoyu Sun, Erqian Cui, Rutao Liu^*. Molecular mechanism of copper–zinc superoxide dismutase activity change exposed to N-acetyl-L-cysteine-capped CdTe quantum dots-induced oxidative damage in mouse primary hepatocytes and nephrocytes, Environmental Science and Pollution Research, 22 (2015): 18267-18277.

16. Haoyu Sun, Xudan Yang, Meng Li, Songlin Han, Yingxue Liu, Xuejie Tan, Chunguang Liu^*, Rutao Liu. Insights into the toxic effect of N-acetyl-L-cysteine-Capped CdTe quantum dots on human serum albumin by spectroscopic techniques, Journal of Luminescence, 167 (2015): 1-7.

17. Haoyu Sun, Erqian Cui, Zhigang Tai, Rutao Liu^*. Effects of N-Acetyl-L-Cysteine-Capped CdTe Quantum Dots on Bovine Serum Albumin and Bovine Hemoglobin: Isothermal Titration Calorimetry and Spectroscopic Investigations, Journal of Biochemical and Molecular Toxicology, 12 (2014): 549-557.

18. Haoyu Sun, Bingjun Yang, Erqian Cui, Rutao Liu^*. Spectroscopic investigations on the effect of N-Acetyl-L-Cysteine-Capped CdTe Quantum Dots on catalase, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 132 (2014): 692-699.

19. Haoyu Sun, Qing Xia, Rutao Liu^*. Comparison of the binding of the dyes Sudan II and Sudan IV to bovine hemoglobin, Journal of Luminescence, 148 (2014): 143-150.

20. 李旭飞, 巫晓丹, 孙昊宇^*, 林志芬. 磺胺类抗生素和纳米银联合暴露对大肠杆菌耐药性的影响, 中国环境科学, 40 (2020): 5045-5054.

21. 林志芬，孙昊宇. 第20章，低浓度化学品Hormesis效应的机制与应用研究进展，环境化学前沿（第二辑）. 2019年8月.

科研项目

(1) 国家自然科学基金青年项目，2021-01至2023-12，24万元，在研，主持。

(2) 中国博士后创新人才支持计划，2019-04至2021-03，60万元，结题，主持。

(3) 中国博士后基金面上项目，2020-01至2021-12，8万元，结题，主持。

(4) 上海市“超级博士后”激励计划，2019至2020，20万元，结题，主持。

(5) 国家水体污染控制与治理科技重大专项（子课题），2018-01至2020-12，200万元，结题，技术骨干。

(6) 国家自然科学基金面上项目，2016-01至2019-12，68万元，结题，参加。

获奖情况

(1) 2019年同济大学优秀毕业研究生

(2) 2016年博士研究生国家奖学金

(3) 2015年博士研究生国家奖学金

(4) 2014年山东大学优秀毕业研究生

(5) 2014年硕士研究生国家奖学金

(6) 2014年山东大学优秀共青团员