职称：研究员，博士生导师

系所：纳米化学与生物学研究所

办公室：亚星221net宝山校区E201-1

E-mail：wei_zhao@shu.edu.cn

个人简介

亚星221net纳米化学与生物学研究所研究员，博士生导师。本科、博士毕业于南京大学化学系，德国Ulm大学博士后，洪堡学者。主要从事单颗粒、单分子、单细胞电化学成像与测量。主持国家自然科学基金面上项目、青年项目，江苏省科技厅青年基金项目。作为骨干参与国家自然科学基金重大科研仪器设备研制专项、重点项目，国家重点研发计划纳米专项。近年来，作为通讯作者在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Nano Letters, ACS Nano, Chem. Sci., Anal. Chem.等SCI期刊发表论文60余篇。

学术经历

1999.9-2003.6 南京大学化学化工学院，化学系，学士

2003.9-2008.6 南京大学化学化工学院，分析化学专业，理学博士

2008.7-2011.5 德国Ulm大学表面化学与催化研究所，洪堡学者

2011.6-2015.6 安捷伦科技上海有限公司，高级工程师

2015.9-2021.1 南京大学化学化工学院，副研究员、特任研究员

2021.3-至今 亚星221net，研究员

研究方向

单颗粒、单分子、单细胞电化学成像与测量

代表性论文

1. M. M. Chen^†, C. H. Xu^†, W. Zhao*, H. Y. Chen, J. J. Xu, Super-Resolution Electrogenerated Chemiluminescence Microscopy for Single-Nanocatalyst Imaging, J. Am. Chem. Soc., 2021, 143, 18511−18518. (IF: 16.383)

2. M. M. Chen^†, C. H. Xu^†, W. Zhao*, H. Y. Chen, J. J. Xu*, Single Cell Imaging of Electrochemiluminescence-Driven Photodynamic Therapy, Angew. Chem. Int. Ed., 2022, e202117401. (IF: 16.823)

3. M. J. Zhu, J. B. Pan, Z. Q. Wu, X. Y. Gao, W. Zhao*, X. H Xia, J. J. Xu*, H. Y. Chen, Electrogenerated Chemiluminescence Imaging of Electrocatalysis at a Single Au-Pt Janus Nanoparticle, Angew. Chem. Int. Ed., 2018, 57, 4010-4014. (IF: 16.823)

4. J. Song^†, C. H. Xu^†, S. Z. Huang, W. Lei, Y. F. Ruan, H. J. Lu, W. Zhao*, J. J. Xu*, H. Y. Chen, Ultra-small Nanopipette: Toward Continuous Monitoring of Redox Metabolism at Subcellular Level, Angew. Chem. Int. Ed., 2018, 57, 13226-13230. (IF: 16.823)

5. J. W. Xue^†, C. H. Xu^†, W. Zhao*, H. Y. Chen, J. J. Xu, Photoinduced Electrogenerated Chemiluminescence Imaging of Plasmonic Photoelectrochemistry at Single Nanocatalysts, Nano Letters, 2023, 23, 4572-4578, (IF: 12.262)

6. M. X. Li^†, C. H. Xu^†, N. Zhang, W. Zhao*, J. J. Xu*, H.Y. Chen, Exploration of the Kinetics of Toehold Mediated Strand Displacement via Plasmon Rulers, ACS Nano, 2018, 12, 3341-3350. (IF: 18.027)

7. W. Zhao, H. Y. Chen, J. J. Xu*, Electrogenerated chemiluminescence detection of single entities, Chem. Sci., 2021, 12, 5720. (IF: 9.969)

8. M. M. Chen, H. L. Hao, W. Zhao*, X. L. Zhao, H. Y. Chen, J. J. Xu*, A plasmon-enhanced theranostic nanoplatform for synergistic chemo-phototherapy of hypoxic tumors in the NIR-II window, Chem. Sci., 2021, 12, 10848. (IF: 9.969)

9. Y. Gu, T. T. Zhang, Z. F. Huang, W. Zhao*, J. J. Xu*, H. Y. Chen, An exploration of nucleic acid liquid biopsy using glucose meter, Chem. Sci., 2018, 9, 3517. (IF: 9. 969)

10. K. Zhang, X. J. Yang, W. Zhao*, M. C. Xu, J. J. Xu*, H. Y. Chen, Regulation and imaging of gene expression via an RNA interference antagonistic biomimetic probe, Chem. Sci., 2017, 8, 4973-4977. (IF: 9. 969)

11. X. L. Li, Z. L. Zhang, W, Zhao*, X. H. Xia, J. J. Xu*, H. Y. Chen, Oriented assembly of invisible probes: towards single mRNA imaging in living cells, Chem. Sci., 2016, 7, 3256-3263. (IF: 9. 969)

12. Y. Zhao, H. Wang, W. Zhao*, X. Zhao, J. J. Xu*, H. Y. Chen, Dark-Field Imaging of Cation Exchange Synthesis of Cu2−xS@Au2S@Au Nanoplates toward the Plasmonic Enhanced Hydrogen Evolution Reaction, ACS Appl. Mater. Interfaces, 2021, 13, 6515−6521. (IF: 10.383)

13. H. Gao, N. Zhang, Y. Li, W. Zhao*, Y. W. Quan, Y. X. Cheng, H. Y. Chen, J. J. Xu*, Trace Ir(III) complex enhanced electrochemiluminescence of AIE-active Pdots in aqueous media, Science China Chemistry, 2020, 63, 715-721, (IF:10.138)

14. S. M. Wang, H. Wang, H. Gao, J. Zhou, W. Zhao*, H. Y. Chen, J. J. Xu*, Single-Particle Plasmonic Sensing of Nitric Oxide in Living Cells, Anal. Chem., 2023, 95, 7062-7069. (IF: 8.008)

15. L. Yu, N. Zhang, J. B. Pan, J. Song, W. Zhao*, H. Y. Chen, J. J. Xu*, Bipolar Electrode Array for Multiplexed Detection of Prostate Cancer Biomarkers, Anal. Chem., 2022, 94, 3005-3012. (IF: 8.008)

16. H. Wang, C. H. Xu, W. Zhao*, H. Y. Chen, J. J. Xu*, Alkaline Phosphatase-Triggered Etching of Au@FeOOH Nanoparticles for Enzyme Level Assay under Dark-Field Microscopy, Anal. Chem., 2021, 93, 10727-10734. (IF: 8.008)

17. Z. H. Xu, H. Gao, N. Zhang, W. Zhao*, Y. X. Cheng, J. J. Xu*, H. Y. Chen, Ultrasensitive Nucleic Acid Assay Based on Cyclometalated Iridium(III) Complex with High Electrochemiluminescence Efficien, Anal. Chem., 2021, 93, 1686-1692. (IF: 8.008)

18. Y. Zhao, X. Y. Gao, H. Wang, J. Wang, J. Zhou, W. Zhao*, J. J. Xu, H. Y. Chen, Ultrasensitive Detection of MicroRNA via a Au@Ag Nanosnowman, Anal. Chem., 2019, 91, 15988-15992. (IF: 8.008)

19. Z. H. Xu, H. Wang, J. Wang, W. Zhao*, J. J. Xu*, H. Y. Chen, Bidirectional Electrochemiluminescent Sensing: An Application in Detecting miRNA-141, Anal. Chem., 2019, 91, 12000-12005. (IF: 8.008)

20. M. X. Li^†, Q. M. Feng^†, Z. Zhou, W. Zhao*, J. J. Xu*, H. Y. Chen, Plasmon-Enhanced Electrochemiluminescence for Nucleic Acid Detection Based on Gold Nanodendrites, Anal. Chem., 2018, 90, 1340-1347. (IF: 8.008)

21. H. J. Lu, J. B. Pan, Y. Z. Wang, S. Y. Ji, W. Zhao*, X. L. Luo, J. J. Xu*, H. Y. Chen, Electrochemiluminescence Energy Resonance Transfer System between RuSi Nanoparticles and Hollow Au Nanocages for Nucleic Acid Detection, Anal. Chem., 2018, 90, 10434-10441. (IF: 8.008)

22. Y. Z. Wang, S. Y. Ji, H. Y. Xu, W. Zhao*, J. J. Xu*, H. Y. Chen, Bidirectional Electrochemiluminescence Color Switch: An Application in Detecting Multimarkers of Prostate Cancer, Anal. Chem., 2018, 90, 3570-3575. (IF: 8.008)

23. Y. Gu, J. Song, M. X. Li, T. T. Zhang, W. Zhao*, J. J. Xu*, M. L. Liu, H. Y. Chen, Ultrasensitive MicroRNA Assay via Surface Plasmon Resonance Responses of Au@Ag Nanorods Etching, Anal. Chem., 2017, 89, 10585-10591. (IF: 8.008)

24. Y. Z. Wang, C. H. Xu, W. Zhao*, Q. Y. Guan, H. Y. Chen, J. J. Xu*, Bipolar Electrode Based Multicolor Electrochemiluminescence Biosensor, Anal. Chem., 2017, 89, 8050-8056. (IF: 8.008)

25. H. R. Zhang, Y. Z. Wang, W. Zhao*, J. J. Xu*, H. Y. Chen, Visual Color-Switch Electrochemiluminescence Biosensing of Cancer Cell Based on Multichannel Bipolar Electrode Chip, Anal. Chem., 2016, 88, 2884-2890. (IF: 8.008)

26. Q. M. Feng^†, Y. Z. Shen^†, M. X. Li^†, Z. L. Zhang, W. Zhao*, J. J. Xu*, H. Y. Chen, Dual-Wavelength Electrochemiluminescence Ratiometry Based on Resonance Energy Transfer between Au Nanoparticles Functionalized g‑C₃N₄ Nanosheet and Ru(bpy)₃²⁺ for microRNA Detection, Anal. Chem., 2016, 88, 937-944. (IF: 8.008)

27. H. W. Shi, W. Zhao*, Z. Liu, X. C. Liu, J. J. Xu*, H. Y. Chen, Temporal Sensing Platform Based on Bipolar Electrode for the Ultrasensitive Detection of Cancer Cells, Anal. Chem., 2016, 88, 8795-8801. (IF: 8.008)

科研项目

国家自然科学基金面上项目，主持

国家自然科学基金青年科学基金项目，主持

江苏省自然科学青年基金，主持

国家重点研发计划纳米专项，课题骨干

获奖情况

2006.6 受邀参加德国林岛诺贝尔奖得主大会（中德科学中心资助）

2008.7 林岛学者（中德科学中心资助）

2009-2011 洪堡学者（德国洪堡基金会资助）

教授课程

本科生通识课程《大自然中的仿生学》

研究生课程《科技英语论文写作》